منابع مشابه
Cytogenetic abnormalities in a plasmacytoma.
By SEnclo MANCINELLI, JOHN R. DURANT, AND WILLIAM J. HAMMACK T SOMEWHAT CONSISTENT cytogenic changes in patients with multiple myeloma have recently been reported. Houston et al.,’ using phytohemagglutinin (PHA) stimulated peripheral blood cells, observed abnormal chromosomes in fifteen of twenty-four patients. The abnormal chromosomes were as large or larger than normal A group members with ce...
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Holoprosencephaly (HPE), the most common developmental defect of the forebrain and midface, is caused by a failure of midline cleavage early in gestation. Isolated HPE, which is highly genetically heterogeneous, can be due to major chromosomal abnormalities. Initially, karyotype approach led to the identification of several recurrent chromosomal anomalies predicting different HPE loci. Subseque...
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The karyotype represents one of the main cornerstones for the International Prognostic Scoring System (IPSS) and the revised IPSS-R (IPSS-R) that are most widely used for prognostication in patients with myelodysplastic syndromes (MDS). The most frequent cytogenetic abnormalities in MDS, i.e. del(5q), -7/del(7q), +8, complex karyotypes, or -Y have been extensively explored for their prognostic ...
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Tumor angiogenesis is necessary for solid tumor progression and metastasis. Tumor blood vessels have been shown to differ from normal counterparts, for example, by changes in morphology. An important concept in tumor angiogenesis is that tumor endothelial cells are assumed to be genetically normal, although these endothelial cells are structurally and functionally abnormal. However, we hypothes...
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ژورنال
عنوان ژورنال: Hematology, Transfusion and Cell Therapy
سال: 2018
ISSN: 2531-1379
DOI: 10.1016/j.htct.2018.01.004